Name:________________________________________  Period:___________________

 

Gene Mutations

 

  1. What is the difference between gene mutations and chromosomal mutations?

 

 

 

  1. What are the two different types of gene mutations?

 

 

 

  1. Indicate whether or not each of the following base pair substitutions would lead to a change in the amino acid sequence causing a point mutation by first converting into the mRNA and then determining the amino acids by using the diagram below:

 

http://wiki.ctl.sri.com/download/attachments/819221/chart.jpg

 

 

 

 

 

 

 

 

 

 

  1. DNA: AAA to AAG (example)

  

mRNA: __UUU to UUC___  amino acids: ____phe to phe___________________ญญ

  1. DNA: AAA to AAC

  

mRNA: _______________  amino acids: __________________________________

 

  1. DNA: TGT to TGC

 

 mRNA: _______________  amino acids: __________________________________

 

  1. DNA: TGT to TGA

  

mRNA: _______________  amino acids: __________________________________

  1. DNA: TGT to GGT

 

 mRNA: _______________  amino acids: __________________________________

  1. DNA:TGT to TTT

 

 mRNA: _______________  amino acids: __________________________________

 

  1. Indicate how the base deletion of A from CTA would lead to a change in the amino acid sequence causing a frameshift mutation by first converting into the mRNA and then determining the amino acids by using the diagram in the above question.

Original DNA:   AAA      CTA    CCG    GGT    ATG    TTG     AAT

 

mRNA: ______________________________________________________________

     

amino acids: __________________________________________________________

 

      Mutated DNA:   AAA     CTC    CGG   GTA    TGT     TGA    AT

 

     

      mRNA: ______________________________________________________________

      

amino acids: __________________________________________________________

 

  1. Which of the two gene mutations (point or frameshift) generally is more harmful to the individual with the mutation? Why.